Adenoid Ameloblastoma of the Mandible: A Rare Histopathological Case Report

Kalaimathi Marimuthu; Madhumitha Durairaju; Nafsina Naseer A K; Arulvizhi Parthibane; B. Premalatha; P. D. Balamurali

doi:10.37841/jidam.2026.v13.i3.003

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Case Report

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Authors

10

References

📝Abstract

📥 Received: 13 August 2026 ✅ Accepted: 22 August 2026 📤 Published: 26 September 2026

Ameloblastoma is the second most common odontogenic tumour, traditionally classified into six histopathological variants. The recent 2022 WHO classification broadened the spectrum of odontogenic lesions by introducing a novel entity, highlighting the evolving nature of jaw pathology. We report a case of this newly recognized entity in a 46-year-old male patient with mild pain in the mandibular anterior teeth region during chewing. Radiographic evaluation revealed a multilocular radiolucent lesion with root resorption. Histopathological examination demonstrated odontogenic epithelial islands with duct-like structures, microcyst formation, squamous metaplasia, and juxta-epithelial hyalinization. IHC confirmed BRAF V600E negativity, supporting the diagnosis of adenoid ameloblastoma. This case emphasizes that deceptively minor symptoms may conceal significant pathology, highlighting the importance of timely recognition.

Keywords: Ameloblastoma Odontogenic Tumors Jaw Neoplasms Neoplasms classification BRAF Mutation

📋How to Cite

Marimuthu K, Durairaju M, Naseer AK N, Parthibane A, Premalatha B, Balamurali PD. Adenoid ameloblastoma of the mandible: a rare histopathological case report. J Indian Dent Assoc Madras. 2026;13(3):17-20. DOI: 10.37841/jidam.2026.v13.i3.003

Marimuthu, K., Durairaju, M., Naseer AK, N., Parthibane, A., Premalatha, B., & Balamurali, P. D. (2026). Adenoid ameloblastoma of the mandible: A rare histopathological case report. Journal of Indian Dental Association Madras, 13(3), 17–20. https://doi.org/10.37841/jidam.2026.v13.i3.003

Marimuthu, Kalaimathi, et al. "Adenoid Ameloblastoma of the Mandible: A Rare Histopathological Case Report." Journal of Indian Dental Association Madras, vol. 13, no. 3, 2026, pp. 17–20. DOI: 10.37841/jidam.2026.v13.i3.003.

Marimuthu K, Durairaju M, Naseer AK N, Parthibane A, Premalatha B, Balamurali PD. Adenoid ameloblastoma of the mandible: a rare histopathological case report. J Indian Dent Assoc Madras. 2026;13(3):17-20. doi:10.37841/jidam.2026.v13.i3.003

Marimuthu, Kalaimathi, Madhumitha Durairaju, Nafsina Naseer A K, Arulvizhi Parthibane, B. Premalatha, and P. D. Balamurali. "Adenoid Ameloblastoma of the Mandible: A Rare Histopathological Case Report." Journal of Indian Dental Association Madras 13, no. 3 (2026): 17–20. https://doi.org/10.37841/jidam.2026.v13.i3.003.

📚References

1
Rajendran R, Sivapathasundharam B. Shafer’s Textbook of Oral Pathology. 7th ed. New Delhi: Elsevier; 2012.
2
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: International Agency for Research on Cancer; 2017.
3
Chaurasia S, Rastogi V, Dhungel D, Karna P. Diagnosing adenoid ameloblastoma: a case report highlighting diagnostic difficulties and histopathological insights. Histopathology. 2024;85(6):846-52. doi: 10.1111/his.15243.
4
Odell EW, Gomes CC, Thavaraj S. The evolving molecular characterisation, histological criteria and nomenclature of adenoid ameloblastoma as a World Health Organisation tumour type. Histopathology. 2024;85(6):846-52.
5
Fadi T, Moegamat S, Johan O. Adenoid ameloblastoma: a case report on this newly recognized under-treated odontogenic tumour. Case Rep Dent. 2024;2024:8366045. doi: 10.1155/2024/8366045.
6
Bastos VC, Coura BP, Guimarães LM, Fernandes BG, Chan AC, Vargas PA, Bastos-Rodrigues L, De Marco LA, Hellstein J, Thavaraj S, Wright JM. Adenoid ameloblastoma harbors beta-catenin mutations. Mod Pathol. 2022;35(11):1562-9. doi: 10.1038/s41379-022-01124-7.
7
Neville BW, Damm DD, Allen CM, Chi AC. Oral and Maxillofacial Pathology. 4th ed. St. Louis: Elsevier; 2023.
8
Sharma G, Kamboj M, Narwal A, Devi A, Singh V. Demystifying histologic conundrum of adenoid ameloblastoma: case report with literature review. Indian J Otolaryngol Head Neck Surg. 2023;75:2432-7. doi: 10.1007/s12070-023-03912-z.
9
Sachdev SS, Chettiankandy TJ, Sardar MA, Adhane Y, Shah AM, Grace AE. Adenoid ameloblastoma with dentinoid: a systematic review. Sultan Qaboos Univ Med J. 2022;22(3):325-38. doi: 10.18295/squmj.9.2021.129.
10
Keshwar S, Raut T, Jain N, Shrestha A, Jaisani MR. Histopathological insight of a case of adenoid ameloblastoma: a rare odontogenic tumor. Case Rep Dent. 2024;2024:8366045.

[1] 1
Rajendran R, Sivapathasundharam B. Shafer’s Textbook of Oral Pathology. 7th ed. New Delhi: Elsevier; 2012.

[2] 2
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: International Agency for Research on Cancer; 2017.

[3] 3
Chaurasia S, Rastogi V, Dhungel D, Karna P. Diagnosing adenoid ameloblastoma: a case report highlighting diagnostic difficulties and histopathological insights. Histopathology. 2024;85(6):846-52. doi: 10.1111/his.15243.

[4] 4
Odell EW, Gomes CC, Thavaraj S. The evolving molecular characterisation, histological criteria and nomenclature of adenoid ameloblastoma as a World Health Organisation tumour type. Histopathology. 2024;85(6):846-52.

[5] 5
Fadi T, Moegamat S, Johan O. Adenoid ameloblastoma: a case report on this newly recognized under-treated odontogenic tumour. Case Rep Dent. 2024;2024:8366045. doi: 10.1155/2024/8366045.

[6] 6
Bastos VC, Coura BP, Guimarães LM, Fernandes BG, Chan AC, Vargas PA, Bastos-Rodrigues L, De Marco LA, Hellstein J, Thavaraj S, Wright JM. Adenoid ameloblastoma harbors beta-catenin mutations. Mod Pathol. 2022;35(11):1562-9. doi: 10.1038/s41379-022-01124-7.

[7] 7
Neville BW, Damm DD, Allen CM, Chi AC. Oral and Maxillofacial Pathology. 4th ed. St. Louis: Elsevier; 2023.

[8] 8
Sharma G, Kamboj M, Narwal A, Devi A, Singh V. Demystifying histologic conundrum of adenoid ameloblastoma: case report with literature review. Indian J Otolaryngol Head Neck Surg. 2023;75:2432-7. doi: 10.1007/s12070-023-03912-z.

[9] 9
Sachdev SS, Chettiankandy TJ, Sardar MA, Adhane Y, Shah AM, Grace AE. Adenoid ameloblastoma with dentinoid: a systematic review. Sultan Qaboos Univ Med J. 2022;22(3):325-38. doi: 10.18295/squmj.9.2021.129.

[10] 10
Keshwar S, Raut T, Jain N, Shrestha A, Jaisani MR. Histopathological insight of a case of adenoid ameloblastoma: a rare odontogenic tumor. Case Rep Dent. 2024;2024:8366045.